ABSTRACT
Background: Pain forms an integral part of many clinical conditions management is of great importance in every field of medicine. The core of medicine is to preserve and restore patient’s health and to minimize their suffering. Toxicodendron radicans (rhus toxicodendron) is a homoeopathic remedy with anti-inflammatory activity used for various arthritic pain. Rhus toxicodendron is commonly used in skin, mucus membrane affections, pain in joints, tendons, rheumatism in cold season, cellulitis and infection, fever. During the recent exponential rise in the use of alternative medicines and increasing integration into the health service little research has been done on alternative medicine in the context in which it is practiced.Methods: Wistar albino rats were divided into four groups. group 1 received control (normal saline), group 2 received vehicle (alcohol with distilled water in ratio 1:4), and group 3 received standard (diclofenac-10 mg/kg), group 4 and 5 consist of 2 test groups-rhus toxicodendron 30x and 200c respectively. Analgesic activity was assessed using Hot water tail immersion method and Eddy’s hot plate method. Preliminary pilot study was done with 4 doses rhus toxicodendron 6x, 12x, 30x, 200c respectively. Data was analysed by one-way ANOVA followed by Tukey Kramer multiple comparison test. P value <0.05 was considered as significant.Results: In Eddy’s hot plate method, rhus toxicodendron 30 showed increase in paw withdrawal time which was statistically very significant at the end of 1 hr compared to the control group whereas statistically rhus toxicodendron 200 showed extremely significant analgesic property. In hot water tail immersion method rhus toxicodendron 30 showed increase in tail withdrawal time at the end of 1hr compared to the control group which was significant statistically.Conclusions: This study shows that toxicodendron radicans homoeopathic formulations possess significant analgesic property.
ABSTRACT
Background: Global burden of disease statistics indicate that 4 of 10 most important causes of disease worldwide are psychiatric in origin. Anxiety affects 1/8th of total population of the world and is a very important area of research interest in psychopharmacology. Medicinal plants and plant products are the oldest tried health-care products. Their importance is growing not only in developing countries but in many developed countries. Curcuma amada Roxb. (CA) commonly known as Mango Ginger is a rhizomatous aromatic herb which is used in this country for culinary purposes and also to treat various diseases. The rhizomes of Curcuma amada was screened for anxiolytic activity and locomotor behavior in Wistar albino rats.Methods: Wistar albino rats were divided into three groups as control (Distilled water with 0.1% CMC), standard (Diazepam - 1mg/kg) and test - Ethanolic Extract of Curcuma amada Rhizome (EECAR-250 mg/kg). They were administered drugs orally for a period of 10 days, and screened for anxiolytic activity using Light dark arena model and Actophotometer for assessing the locomotor behavior on the 10th day. The number of crossings and time spent in light arena for anxiolytic activity, and the number of movements in Actophotometer was noted. Data was analyzed by one way ANOVA followed by Tukey Kramer multiple comparison test using GraphPad InStat software.Results: Curcuma amada (250mg/kg) showed increased time spent in light arena and decreased locomotor behavior which was statistically significant.Conclusions: Curcuma amada possesses significant anxiolytic with CNS depressant activity.